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In this article
  1. Exploring Red Light Therapy
  2. Methylene Blue in Photodynamic Therapy
  3. Benefits of Combining Methylene Blue with Red Light Therapy
  4. Potential Side Effects
  5. Future Prospects
  6. Conclusion

The use of methylene blue supplemented with red light therapy has attracted the attention of the medical community in recent years. Various studies have proven that this novel approach has been effective in improving the functionality of cells as well as treating different illnesses. It also discusses how exactly each therapy works, synergistic effects, optimal doses of the combined therapies, possible side effects, and prospects for further development of this treatment.

Exploring Red Light Therapy

Red light therapy, or RLT, uses low-level red light that can easily penetrate the skin and get into the deep layers of the tissue in order to promote the healing and energy production of the cells. This form of therapy is famous for its efficiency in treating skin problems, decreasing inflammation, and enhancing skin tone. It is also involved in energy synthesis within the cells, which is important for many functions in the body.

Methylene Blue in Photodynamic Therapy

Pharmaceuticals | Free Full-Text | Photodynamic Action of Curcumin and Methylene  Blue against Bacteria and SARS-CoV-2—A Review

Methylene blue, which is a dynamic compound that has been employed in the medical field for staining, has recently been used in photodynamic therapy. In this case, it is used as a photosensitizer, which is a compound that is activated by light. When applied together with light treatment, methylene blue increases the penetration of light into the tissues and thus increases the effectiveness of the treatment aimed at pathogens and damaged cells.

Benefits of Combining Methylene Blue with Red Light Therapy

The use of methylene blue in combination with red light therapy is greater than the mere use of the two separately. This pairing accelerates cellular respiration and creates more ATP (adenosine triphosphate), which is the cell's energy currency. This increase in energy is not only useful in quickening the healing process but also in strengthening the bodily defense against diseases. Furthermore, this combination has shown positive effects on cognitive functions and memory; therefore, it can be used as a therapy for age-related cognitive disorders.

Potential Side Effects

Chromotherapy and LED face therapy with HydraFacial device

It is important to note that although this combination of methylene blue and red-light therapy is safe, there are side effects that are attributed to each treatment. Methylene blue may momentarily stain the urine and sometimes the stool, but it is not a concern. There are more severe, albeit less frequent, side effects, which include nausea, dizziness, or high blood pressure. Similarly, severe side effects related to red light therapy are relatively rare but can lead to skin irritation and redness in susceptible individuals.

Future Prospects

Methylene blue and red-light therapy are still areas of research, and several research studies are being conducted to determine the effectiveness of the treatment in conditions such as neurodegenerative diseases, skin diseases, and cancer. The future of this therapy seems to be quite bright, given that its applicability is only going to increase with a better understanding of how this therapy works. 


The use of methylene blue and red light is a good example of merging traditional and current forms of treatment to boost health. In years, as one research builds on another, this combination therapy will likely permanently establish itself in various treatment regimens for numerous disorders, improving the quality of life of patients globally through its novel approach to optimizing cell and treatment performance.



[1] Sorbellini, Elisabetta, Maria Pia De Padova, and Fabio Rinaldi. "Coupled blue and red light-emitting diodes therapy efficacy in patients with rosacea: two case reports." Journal of medical case reports 14 (2020): 1-5.

[2] Alechine, Evgenia. "Methylene Blue and Red Light: The Colors of Neuroprotection."

 [3] Songsantiphap, Chankiat, Jakapat Vanichanan, Tanittha Chatsuwan, Pravit Asawanonda, and Einapak Boontaveeyuwat. "Methylene Blue–Mediated Antimicrobial​ Photodynamic Therapy Against Clinical Isolates of Extensively Drug Resistant​ Gram-Negative Bacteria Causing Nosocomial Infections in Thailand, An In Vitro Study." Frontiers in Cellular and Infection Microbiology 12 (2022): 929242.


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